FUNCTIONAL GENOMICS IDENTIFIES TIS21-DEPENDENT MECHANISMS AND PUTATIVE CANCER DRUG TARGETS UNDERLYING MEDULLOBLASTOMA SHH-TYPE DEVELOPMENT

We have recently generated a novel medulloblastoma (MB) mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1+-Tis21KO).ts main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs).By genomic analysis of GCPs in tenga flip orb vivo, we identified as drug target and major responsi

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Beneficiation of corncob and sugarcane bagasse for energy generation and materials development in Nigeria and South Africa: A short overview

The challenges of increasing energy demand and advanced materials for infrastructural development in developing countries have necessitated the search for sustainable cartoon martian with big head sources of raw materials.The high amount of agricultural residues generated in Africa owing to vast availability of arable land has been an impetus for s

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